2. Signaling Pathways
  3. GPCR/G Protein
  4. Vasopressin Receptor
  5. Vasopressin Receptor Inhibitor

Vasopressin Receptor Inhibitor

Vasopressin Receptor Isoform Comparison

Vasopressin Receptor Inhibitors (11):

Cat. No. Product Name Effect Purity
  • HY-165456
    AGN-190851
    		Inhibitor
    AGN-190851 is a potent and selective agonist of α2-adrenergic receptor (α2 adrenoceptor). AGN-190851 induces dose-dependent water diuresis in rats, and inhibits vasopressin V2 receptor in a species-dependent manner in vitro, thereby suppressing cAMP production. AGN-190851 enhances the contraction of porcine myometrium. AGN 190851 can be used in studies on renal diuretic mechanisms, pharmacology of α2-adrenergic receptor subtypes, and parturition.
  • HY-B0662
    Imidafenacin
    		Inhibitor 99.26%
    Imidafenacin (KRP-197; ONO-8025) is an orally active inhibitor of muscarinic (mAChR) M1 and M3 receptors. Imidafenacin potently inhibits bladder contraction in vivo and exerts an antidiuretic effect by enhancing the signaling pathway of vasopressin (antidiuretic hormone). Imidafenacin can be used in research related to overactive bladder.
  • HY-W158030
    2-Guanidinobezimidazole
    		Inhibitor
    2-Guanidinobezimidazole (2GBI) is a NLRP3 agonist with a KD of 1.29 μM and a selective state-dependent HVCN1 blocker. 2-Guanidinobezimidazole directly binds NLRP3’s LRR domain, enhances NLRP3-ASC and NLRP3-NEK7 interactions, and drives NLRP3 inflammasome activation. 2-Guanidinobezimidazole can be used for the research of LLC lung carcinoma, B16F10 melanoma and ischemic stroke.
  • HY-P0041A
    F992 TFA
    		Inhibitor 98.19%
    F992 TFA is an antidiuretic peptide and vasopressin (antidiuretic hormone) analogue.
  • HY-W583271
    Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol
    		Inhibitor
    Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol is a heme oxygenase (HO) inhibitor, and inhibiting HO activity can reduce the release of hypothalamic hormones like AVP, OT, and ANP caused by hyperosmolarity. Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol can be used for research on hyperbilirubinemia.
  • HY-105652
    Ambucetamide
    		Inhibitor
    Ambucetamide is an antispasmodic agent. Ambucetamide alleviates menstrual pain.
  • HY-P0041
    F992
    		Inhibitor
    F992 is an antidiuretic peptide and vasopressin (antidiuretic hormone) analogue.
  • HY-109133
    Pecavaptan
    		Inhibitor
    Pecavaptan, a chemical probe, is an orally active and dual antagonist of V1a/V2 receptor (Ki=0.5 nM and 0.6 nM for human, respectively). Pecavaptan promotes an increase in urine production, which reduces the associated symptoms of water retention and edema.
  • HY-B0662A
    Imidafenacin hydrochloride
    		Inhibitor
    Imidafenacin (KRP-197; ONO-8025) hydrochloride is an orally active inhibitor of muscarinic (mAChR) M1 and M3 receptors. Imidafenacin hydrochloride potently inhibits bladder contraction in vivo and exerts an antidiuretic effect by enhancing the signaling pathway of vasopressin (antidiuretic hormone). Imidafenacin hydrochloride can be used in research related to overactive bladder.
  • HY-P10046
    [Deamino-Pen1,Val4,D-Arg8]-vasopressin
    		Inhibitor
    [Deamino-Pen1,Val4,D-Arg8]-vasopressin (AVP-A) is an arginine-vasopressin (AVP) antagonist. AVP-A can significantly lower plasma aldosterone concentration in rats. AVP-A can be used for the research of the growth and steroidogenic capacity of rat adrenal zona glomerulosa.
  • HY-165423
    DM-4111
    		Inhibitor
    DM-4111, one of the major monohydroxyl metabolites of Tolvaptan (HY-17000), is a potent vasopressin V2 receptor inhibitor. DM-4111 inhibits water reabsorption in the renal tubules, thereby promoting the excretion of electrolyte-free water. DM-4111 is promising for research of cardiovascular diseases.